A selection of neuron-derived signals that induce long-lasting neurosupportive functions in astrocytes
The green arrows and proteins/processes illustrate the impact of neuronal activity on astrocytic glucose uptake, glycolysis, and lactate export via the cAMP/PKA-dependent activation of CREB-dependent genes in the aforementioned pathway [25]. Note that the precise signal (and therefore receptor) released by active neurons awaits discovery. The pink proteins highlight the role of astrocytic neuroligin–neurexin signalling in both driving morphological complexity and excitatory synapse formation [14]. The blue arrows and proteins/processes illustrate the impact of neuron-to-astrocyte notch signalling on expression and functional activity of neurotransmitter uptake [25]. The red arrows and proteins/processes illustrate the adaptive-protective response of astrocytes to Aß pathology [60].