Activation of CaMKK2 via its interaction with Ca²⁺/calmodulin results in the activation of downstream signalling pathways through kinases AMPK, CaMKI, CaMKIV and protein kinase B (PKB). This drives functions related to metabolic regulation and transcriptional regulation. In addition to these activities, CaMKK2 regulates multiple membrane trafficking pathways, which include autophagy, clathrin-mediated endocytosis and Golgi vesicle trafficking. Regulation of these membrane trafficking pathways is important for cellular control of metabolism and cell survival. Figure created with BioRender.com.