Figure 2.
Schematic diagram of the viral proteins interacting with protein complexes involved in regulating cell polarity.
In apical-basal cell polarity, cellular regions are divided into the apical, basal and lateral regions. Viral effector proteins (red) interact with polarity proteins. The Crumbs complex (orange) is composed of Crb, Pals and Patj and the Par complex (pink) composed of Par3, Par6 and aPKC are in the apical region. The Scribble module (blue) includes Scribble, Dlg and Llg in the lateral-basal region. Mutual antagonistic interactions exist between the complexes to establish the orientation of the cell. Figure adapted from Humbert et al. (2003).