(A) Non-amyloidogenic APP processing. First, APP is cleaved by ADAM10 leading to the production of C83 and sAPPα. Next, C83 is cleaved γ-secretase leading to the production of AICD and p3. (B) Amyloidogenic processing. First, APP is cleaved by BACE1 leading to the production of C99 and sAPPβ. Next, C99 is cleaved by γ-secretase leading to the production of AICD and Aβ. Created using Biorender.