By targeting the receptor cells or through nonspecific macropinocytosis or micropinocytosis, these vesicles, used as ‘carriers’ for communication between cells, can carry proteins, lipids, nucleic acids, and other bioactive molecules to transmit signals between cells. Once the EVs enter the target cells, they can directly release the bioactive molecular goods carried into the cytoplasm, or they can be recovered and re-secreted or degraded by lysosomes.