Targeting cell division and FtsZ for anti-bacterial therapy
Z-ring dynamics during normal cell division drive the successful separation of daughter cells after cytokinesis. The inhibition of FtsZ by anti-bacterial agents leads to the disruption of the Z-ring dynamics, finally leading to cell division block usually visualized as a filamentous phenotype of the elongated but undivided cells. DIC images of Bacillus subtilis 168 cells bear scale bar of 5 μm (unpublished data) (Cartoon images were created using BioRender.com)