(A) Cartoon representation of the refined models of EhCFIm25 and Ehnopp34. The Nudix domain of EhCFIm25 is shown in marine blue and the RRM domain of Ehnopp34 is highlighted in purple. (B) Superposition (upper panel) of the Nudix domains of EhCFIm25 (pale blue) and HsCFIm25 (green). The structures of the RRM domains of Ehnopp34, HsCFIm68 (3Q2T), UPB1 of Trypanosoma cruzi (1U6F), RNA15 of Saccharomyces cerevisiae (2X1B), and human RBM7 (5IQQ) are shown at the bottom. (C) On the left side, the RMSD graphs of the MD trajectory during the 100 ns of simulation are shown. The RMSD values of full-length EhCFIm25 (gray) and Ehnopp34 (black) were compared with those observed for the Nudix (blue) and RRM (green) domains of EhCFIm25 and Ehnopp34, respectively. On the right side, snapshots of structures obtained at different times of the MD showing the movement of the N-terminal segment of EhCFIm25 (N) and of the C-terminal segment of Ehnopp34 (C) through dynamics. (D) Graph of RMSF values through MD of EhCFIm25 (gray), Ehnopp34 (black), the Nudix domain of EhCFIm25 (blue) and the RRM domain of Ehnopp34 (green). The average structures of EhCFIm25 and Ehnopp34 are shown in the figure insert and are colored according to chain mobility during MD (rigid regions in blue and flexible regions in red). (E) R_g graph for EhCFIm25 (grey), Ehnopp34 (black), the Nudix domain of EhCFIm25 (blue) and the RRM domain of Ehnopp34 (green).