Figure 1
Schematic illustration of anti-amyloidogenic and cytoprotective effects exerted by metallic/inorganic, polymeric and self-assembled nanoparticles against in vitro and in vivo Aβ fibrillation process
Both inorganic and polymeric nanoparticles share almost similar mode of action to ameliorate Aβ induced toxicity by binding to different intermediates (i.e. the different forms of Aβ species found during the fibrillation process such as monomeric species, oligomeric species etc.) of fibrillation process and by neutralizing their toxic effects. The plot of “Fibrils vs Incubation Time” has been reprinted (adopted) with permission from “Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation, Takahashi T, Mihara H., Acc Chem Res. 2008, 41(10),:1309–1318. doi: 10.1021/ar8000475. Copyright (2008) American Chemical Society”.