The β1-AAb promotes the atrial enlargements and atrial fibrosis
(A) Schematic diagram of echocardiography of three groups. Yellow circle indicates LA location. (B–F) comparison of LAD, RAD, LVEF, LVEDd, and LVESd among three groups at the baseline and endpoint, (n=7) per group. (G,H) Pearson correlation of the β1-AAb titers at the 8th week with atrial diameters, (n=7) per group. (I) Typical Masson’s trichrome staining of left atrium among the three groups. The blue areas indicate the collagen depositions, (×20). (J) quantitative statistics of positive collagen areas, (n=7) per group, *P<0.05 indicates statistical significance. (K) Pearson correlation of β1-AAb titers at the 8th week with the positive collagen areas of atrium sections, (n=7) per group, *P<0.05 indicates statistical significance. *P<0.05 indicates statistical significance. LAD, left atrial diameter; LVEDd, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; LVESd, left ventricular end-systolic dimension; RAD, right atrial diameter. *P<0.05 indicates statistical significance.