JIP1, β-Arrestin-2, Filamin B and WDR62 are amongst the best described JNK scaffold proteins and are known to assemble JNK network components in response to extracellular stress stimuli to induce apoptosis. In the context of gastric and breast cancers, two scaffold proteins, Synaptotagmin 11 (SYT11) and SH3RF3, have recently been shown to promote disease progression through the positive regulation of cancer stem cell populations.