Figure 3.
![*(R)-hydroperoxides in humans are exclusively formed by 12(R)-LOX in the epidermis and can be further metabolized to 9(R)-HODE or to hydroxy–epoxy metabolites by eLOX3 [48]. Mice have been shown to produce 9(S)-hydroperoxide from LA by 15-LOX-2, which is then metabolized to 9(S)-HODE [40]. sEH, soluble epoxide hydrolase; DH, dehydrogenase.](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/50/6/10.1042_bst20210644/1/bst-2021-0644c.03.png?Expires=1716524278&Signature=gM33CXrRAxFucyvLgk39EMm55gkagPwStrxEQe1pVSQwf1rARcSG2KCYQxOZsCpN~qG~XJ8fjsIbnzyh1oXuJLhdl125kveba0YtJU3ahxehKrX3mPhnSrjw7QxakII0GHtOWpMH1JswDdumZRdmAuhlsTGW8xljJ6yndEJ0dojX3gpM79mQ7OaI~dRbIhBLGUMW9L3u3pS8swbM7kD0m-LNmKaYf5Lb-FVcT7H0FOvhPJNFji7YxemN-0meJDFEEmX5t4ZFO~hEJbH5SCMgKSLU-NZlbPeaAX~yYvPg53OX3gpKzdKdBjQHe1MPkl8Zh5lvWYTrbXQyM4-iiclyMQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Principal mechanisms for the main enzymatic pathways of LA metabolism in humans.
*(R)-hydroperoxides in humans are exclusively formed by 12(R)-LOX in the epidermis and can be further metabolized to 9(R)-HODE or to hydroxy–epoxy metabolites by eLOX3 [48]. Mice have been shown to produce 9(S)-hydroperoxide from LA by 15-LOX-2, which is then metabolized to 9(S)-HODE [40]. sEH, soluble epoxide hydrolase; DH, dehydrogenase.