Figure 3.
![(A) In a beta-cell, the glucose and Ach signaling lead to the influx of Ca2+ from outside or the release of Ca2+ from the insulin-secretory granules. CHGB channels are in both the granular membranes and the plasma membranes and may participate in both pathways. (B) CHGB channels go through the endomembrane system, be taken from the cell surface and distributed to the endosomal compartments. CLC transporter proteins are not sorted into the regulated secretory pathway. EE: early endosomes; LE: late endosomes; ERC: endosomal recycling compartments; TGN: trans-Golgi network. Panel B was adapted from ref. [1] with permissions following the PubMed Open Access policies.](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/50/6/10.1042_bst20220435/1/bst-2022-0435c.03.png?Expires=1716903086&Signature=moRjkzspMd9~4-fGwxWepn3QQync0nmmj6OtryBD8z4AnbapS4N8IaGjQp-LyZ7yZhhNw1or2BngvQLqQ5ad6arHLOe9q8cVei9aauT9neeXrOqBFcxlHqkvVjdGE~NhIi-Q4fmwFxGjTsLwmlXYF9h82yB6Ju~VQYSdkH9B4wN4XQRdeRMezkK0-1GrXowSzWp8wmI8SOBEHdfm0kDWz~tvCFIpSkJYh2I-pbeVJVldOGdS3WBYXmkkb0DrAjUjn3gEms8P8y~STO1t1iD68z-v5Nt1wkJxeA2vuZrIZ1clZhyp20OXksTO9yfpHvekFMM3Lo3VFSR5~Wxwh1YHFg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CHGB channel functions in granule release and its distribution among endomembranes and membrane trafficking pathways in a secretory cell.
(A) In a beta-cell, the glucose and Ach signaling lead to the influx of Ca2+ from outside or the release of Ca2+ from the insulin-secretory granules. CHGB channels are in both the granular membranes and the plasma membranes and may participate in both pathways. (B) CHGB channels go through the endomembrane system, be taken from the cell surface and distributed to the endosomal compartments. CLC transporter proteins are not sorted into the regulated secretory pathway. EE: early endosomes; LE: late endosomes; ERC: endosomal recycling compartments; TGN: trans-Golgi network. Panel B was adapted from ref. [1] with permissions following the PubMed Open Access policies.