Protein interactions with low MBM sample only one binding mode (unimodal), which can be ordered (blue, p53/Mdm2 complex [12]) or disordered (orange, Gcn4/Med15 complex [18]). Context-dependent protein interactions have high MBM, as they sample multiple binding modes (multimodal) in between ordered (blue) and disordered (orange) modes (p53/HMGB1 complex [11]). The distributions show the frequencies of different binding modes, which can be sampled under different cellular conditions or partners. These can be evaluated using the computational methods described in Ref. [38].