Figure 4
![CryoEM structures for tauopathy derived filaments showing the conformation of the building blocks viewed down the fibre axis using spheres for the atoms. (A) Straight filaments (SF) from AD brain [48] (6HRF), filaments from cortical basal degeneration [49] (6TJX), (C) filaments from Pick’s disease [50] (6GX5), (D) filaments from chronic traumatic encephalopathy [51] (6NWQ), (E) paired helical filaments from AD brain ([48] (6HRE) and (F) shows a predicted structure of 2N4R using alphafold (https://alphafold.ebi.ac.uk) [52].](https://port.silverchair-cdn.com/port/content_public/journal/essaysbiochem/66/7/10.1042_ebc20220150/1/ebc-2022-0150ci004.png?Expires=1716612961&Signature=K6QJB1go0q6SKrC5XRptAdHbochiqxW9RFL1~sJ2imqbGZ0JTQFxoTi4lERr5r2C4Zj19UUshTQfNyCaN~d1EER00BZm~W2eMqd9UaiVfU6SjdnzHhHHko5VgOmiAVFD2TjRXU7LRfneKAC9yz8SGjRwC6vA9rlQExUsaP8ii-zJJe3E6SbJYR61BYa6e2VgkOmf-g~Jp7d3xKznWovoMLD74FZaR6li3KRjHh0IqidIWS4~T9mKQiqEKI19M-~8folHvhLoqjHQvqum3o0-GvWX-F4PL4KAvWxospi1hDc86vQtQVDxvH52vMPtWkaRwaoXLuMAnvhh4Ew0Ki39kw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Structures of tau
CryoEM structures for tauopathy derived filaments showing the conformation of the building blocks viewed down the fibre axis using spheres for the atoms. (A) Straight filaments (SF) from AD brain [48] (6HRF), filaments from cortical basal degeneration [49] (6TJX), (C) filaments from Pick’s disease [50] (6GX5), (D) filaments from chronic traumatic encephalopathy [51] (6NWQ), (E) paired helical filaments from AD brain ([48] (6HRE) and (F) shows a predicted structure of 2N4R using alphafold (https://alphafold.ebi.ac.uk) [52].