Effects of phosphorylation of IDPs on the structure and ensembles
(A) Structural effects upon phosphorylation of IDPs. Secondary structure stabilization (top), destabilization (second row), proline cis-trans isomerization (third row) and global folding (bottom). (B) Global conformational ensemble distribution changes upon multisite phosphorylation of IDPs leading to expansion (top), compaction (middle), or no change (bottom) dependent on the chain’s original properties as well as other PTMs (Adapted from [28]). (C) Supramolecular assemblies of IDPs depend on phosphorylation, leading to coacervates or aggregation or fibrils (top) or the dissolution of the coacervates (bottom), where csat is the saturation concentration and NCPR is the net charge per residue [77].