Structure of TW10 presented by HLA-B*5701 and recognised by KIR3DL1.
(A) Structure of HLA-B*57:01 (pale grey cartoon) presenting the T242N mutant peptide of TW10 (pale orange stick and cartoon). The T242N at position 3 of the TW10 peptide is labelled in red on the panel. (B) Superposition of the HLA-B*57:01 (pale grey cartoon) structures in complex with the TW10 (orange) and T242N (pale orange) peptides. (C) Structure of the complex between the KIR3DL1 (pink cartoon) docking onto the HLA-B*57:01 (pale grey cartoon) presenting the TW10 peptide (red cartoon). (D) Superposition of the HLA-B*57:01 (pale grey cartoon) presenting the TW10 peptide free (orange cartoon) or the TW10 peptide bound to the KIR3DL1 (red cartoon). (E) Structure of the complex between the KIR3DL1 (pale yellow cartoon) docking onto the HLA-B*57:01 (pale grey cartoon) presenting the T242N peptide (pale orange cartoon). (F) Superposition of the KIR3DL1-HLA-B*57:01-TW10 structure with the KIR3DL1-HLA-B*57:01-T242N structure using the same colour scheme as per panel (C) and (E).