Figure 2
The luminal epithelial cells are defined by expression of CK8 and CK18 and AR. The basal epithelial cells express high levels of CK5 and p63 and very low levels of AR. Neuroendocrine cells are a small population of endocrine–paracrine cells. Neuroendocrine cells express neuroendocrine markers such as synaptophysin and chromogranin A and do not express AR [86]. The stroma is populated by fibroblasts, immune cells, smooth muscle cells and varies subtypes of neural cells, such as TH+, NES+, and β-Tubulin III+ nerve fibers and abundant GFAP+ cells [83]. Figure is modified from [85] and [83].
A schematic illustrating the cellular architecture of the prostate epithelium and ECM and stromal cells in the normal prostate gland

The luminal epithelial cells are defined by expression of CK8 and CK18 and AR. The basal epithelial cells express high levels of CK5 and p63 and very low levels of AR. Neuroendocrine cells are a small population of endocrine–paracrine cells. Neuroendocrine cells express neuroendocrine markers such as synaptophysin and chromogranin A and do not express AR [86]. The stroma is populated by fibroblasts, immune cells, smooth muscle cells and varies subtypes of neural cells, such as TH+, NES+, and β-Tubulin III+ nerve fibers and abundant GFAP+ cells [83]. Figure is modified from [85] and [83].

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