Figure 1.
![(A) The N-terminus harbors the sequences relevant to the kinase catalytic function within the kinase domain (green), including the ATP-binding site, the S/T kinase active site and a Thr–Glu–Tyr (TEY) motif. The C-terminus (blue) contains sequences involved in nuclear localization, including NLS (nuclear localization signal) and NES (nuclear export signal) sequences. Figure adapted from Fehr et al. [33]. (B) Consensus CDKL5 phospho-motif identified in known CDKL5 targets. (C) Shared properties of amino acids within the known CDKL5 phosphorylation motif demonstrate that the C-terminal residues are similar. Euler Venn diagram adapted from Taylor et al. [40].](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/50/4/10.1042_bst20220791/1/bst-2022-0791.01.png?Expires=1716613143&Signature=X9OH0fecw2KXHkXiLIsbxJGoydSCzTNKjR1ZOGdO~C478AOZH-Po1UBo2H11V6UuUgHTkP1xJYAXIF-sy5DRCmSKZ7EkBYUKe0NjgM-gCsHgqV6LECkufFRAPewuczXFKXGhNJxIwpTN7gaJyUAEOhvAGV17kjTpqfiFIQsZweYx7l1k9FSDwDzLS4WRfjC7MZdmDQ6FVHDFpxqpN~FKGBU~A2HhPLdx6LLZXtIsFRxe4MlwToD89yqUBXiAbp0ajP8-uS~mzlO3IjMrLxV84SoBmJCVkyWO3d4pwBhYgTig9Q5nNgPCgp~9dI5jXY1EzlmKOTN8hCUik2bVtcXFBA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CDKL5 protein domains consensus sequence in phosphorylation targets.
(A) The N-terminus harbors the sequences relevant to the kinase catalytic function within the kinase domain (green), including the ATP-binding site, the S/T kinase active site and a Thr–Glu–Tyr (TEY) motif. The C-terminus (blue) contains sequences involved in nuclear localization, including NLS (nuclear localization signal) and NES (nuclear export signal) sequences. Figure adapted from Fehr et al. [33]. (B) Consensus CDKL5 phospho-motif identified in known CDKL5 targets. (C) Shared properties of amino acids within the known CDKL5 phosphorylation motif demonstrate that the C-terminal residues are similar. Euler Venn diagram adapted from Taylor et al. [40].