Specifically highlighting 1. PDAC development and the acquisition of a motile phenotype, 2. Increased growth and invasion into adjacent tissue, followed by 3. Intravasation in nearby vasculature. Once in the vasculature 4. Cells transit in the circulatory system until 5. Arrest or mechanical trapping and extravasation with subsequent 6. Metastatic outgrowth at secondary sites such as the liver.