Figure 1
Selective autophagy receptors (SARs) bring their substrate to the nascent autophagosome ATG8 interaction. Substrate binding can be ubiquitin-dependent or -independent. The cargo for xenophagy and effectorphagy includes viral proteins and bacterial effectors. Protein aggregates are targeted in aggrephagy. Organelles such as endoplasmic reticulum (ER), proteasome, and mitochondria are the cargo for ER-phagy, proteaphagy and mitophagy respectively. Specific proteins such as FLS2 and BES1 have also been found to be targeted by SARs. Examples were highlighted based on data availability on ubiquitin-binding and AIM/LIR/UIM-containing. For a comprehensive review on receptors and their substrates see [19,20,25].
Selective autophagy is involved in the degradation of cellular and pathogenic components

Selective autophagy receptors (SARs) bring their substrate to the nascent autophagosome ATG8 interaction. Substrate binding can be ubiquitin-dependent or -independent. The cargo for xenophagy and effectorphagy includes viral proteins and bacterial effectors. Protein aggregates are targeted in aggrephagy. Organelles such as endoplasmic reticulum (ER), proteasome, and mitochondria are the cargo for ER-phagy, proteaphagy and mitophagy respectively. Specific proteins such as FLS2 and BES1 have also been found to be targeted by SARs. Examples were highlighted based on data availability on ubiquitin-binding and AIM/LIR/UIM-containing. For a comprehensive review on receptors and their substrates see [19,20,25].

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