(A) Peroxisomes are targeted for pexophagy by recruitment of autophagy machinery, including a double-bilayer isolation membrane marked by ATG8 (violet circles). Recruitment could occur through direct interaction of peroxisomal proteins with ATG8 or via an intermediary receptor (purple ovals) that recognizes peroxisomal proteins or their ubiquitinated (Ub) derivates. Illustrated targeting mechanisms are based on receptor-mediated partners observed in non-plant systems or demonstrated ATG8 interactions in plants; none of the interactions depicted have been shown as necessary or sufficient to induce pexophagy in plants. (B) Following recruitment of the isolation membrane, cargo is fully engulfed to form an autophagosome. Contents are delivered through fusion of the outer autophagosomal membrane with the vacuolar membrane. In the vacuole, resident proteases and lipases degrade the peroxisomal proteins and lipids to allow nutrient recycling.