The PPI networks of DEGs
(A) KO versus WT, (B) KE versus KO, (C) WE versus WT, (D) KE versus WT, and (E) KE versus WE. The PPI networks were constructed by the proteins represented by nodes and interactions represented by the edges between nodes. The nodes size represents the value of degree, and the edge thickness represents the intensity of interactions. Separately, orange and blue nodes represent up-regulated and down-regulated genes, with red and green nodes representing the top 10 up-regulated and down-regulated genes. (F) The PPI network was constructed by Asmt, MT receptors (Mtnr1a and Mtnr1b), Bdnf, verified DEGs (Eps8l1 and Plcb2), failed-verified DEGs (Chek1, Cdkn1a, Itpr2, Mdm4, Pidd1, Hspa1b), the first-order neighbors of Eps8l1 (Cask, Sos1, Abi1) and Plcb2 (Gna11). The color and shape of nodes represents different kinds of proteins, and the edge thickness represents the intensity of interactions.