Figure 5.
![Several E3s, including ITCH, WWP1, PIRH2, PIR2/Rnf144B and MDM2 acting in concert with FBXW7, determine the ubiquitin-dependent degradation of p63 — through the formation of K48 polyubiquitin chains [92, 93, 105, 107]. WWP1 is also able to inhibit p63 transcriptional activity through K63 polyubiquitination. The mono-ubiquitination mediated by MDM2 allows p63 to translocate into the cytoplasm, ultimately inhibiting its transcriptional activity.](https://port.silverchair-cdn.com/port/content_public/journal/biochemj/479/12/10.1042_bcj20210737/1/bcj-2021-0737c.05.png?Expires=1716491326&Signature=jJLRkLobQ1FRdGSjmYyjhTsHLZXVw-HHwgi59FvM~x1gBkvHIhn0BdNh8l-mxGKAoKwtiUcXp0MbUBELhVUNdVMAjuGqNXccC4zvKey9AkMJmVaWLdrkh3UT4J1heWfJ-ccw1qucsByfcmWciqhJGytEMjxxlj9CLsvCwAMv1BHacZSZB0tWC0Om~nGBE7OKs4TZn9RDFEfnlm19evp69nFzkFVmP~UsB21LCwjhQ7kdjzD3SoWroXW8wMG~hpP8d4Zn3R3eFq0N3S7nAoFOBH9Ytl45rPW2e4QIqxDMQuC8nX8EkXdfUKzijAR3b1ZcVFjVRBjjd~nScqz7pheHXA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
E3s involved in the regulation of p63 stabilization and transcriptional functions.
Several E3s, including ITCH, WWP1, PIRH2, PIR2/Rnf144B and MDM2 acting in concert with FBXW7, determine the ubiquitin-dependent degradation of p63 — through the formation of K48 polyubiquitin chains [92, 93, 105, 107]. WWP1 is also able to inhibit p63 transcriptional activity through K63 polyubiquitination. The mono-ubiquitination mediated by MDM2 allows p63 to translocate into the cytoplasm, ultimately inhibiting its transcriptional activity.