Figure 3.
![On the left side, the core model is shown (dark cyan). On the right side, additional species and reactions that were used to extend the model are shown in orange. Top: HGF-induced ERK and AKT activation extended by interaction of MET with integrin α5β1 [60]. Middle: EGFR activation by multisite phosphorylation extended by CBL-based ubiquitination and internalization of EGFR [69]. Bottom: TNFα-induced NFκB signal transduction extended by specific A20 regulation mechanisms [75].](https://port.silverchair-cdn.com/port/content_public/journal/biochemj/479/12/10.1042_bcj20210548/1/bcj-2021-0548c.03.png?Expires=1716277008&Signature=LJ~rq3gyUwhPCKn09K2xmGjllB5MGqIaDYtkfUzCjx0Q7kP-Wd~-~fEggbijiAzk8C0WdNChaEJpNzEkvQAdMMC2E-BjXGKqIhlkLqgXf5fUf0urpTpcK6zrwpZBaC2RLZ1B8YluOm~0P8xDbUnjwzjcao5XxpJ8UEib~cCOUB0BZfu8dZF7CZEDUH2hCNx~n~-e02zAg11HlsP8nbruvTnWkIvawD0aZb08m8wN2nai-2xTPHV401VlxzoNa7qUnLWMIcFShOh4iAuW2L-e19uRI--PQc9ppNcAC8w-Mx5DJbh7TxpBBCCoaY6C~ZntYlW8QLrGTwJabagV~CzHVg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Modular approaches that were used for mechanistic mathematical modelling.
On the left side, the core model is shown (dark cyan). On the right side, additional species and reactions that were used to extend the model are shown in orange. Top: HGF-induced ERK and AKT activation extended by interaction of MET with integrin α5β1 [60]. Middle: EGFR activation by multisite phosphorylation extended by CBL-based ubiquitination and internalization of EGFR [69]. Bottom: TNFα-induced NFκB signal transduction extended by specific A20 regulation mechanisms [75].