LFDE motif binding is not observed in the LiBRC1:LiRAD51 crystal structure.
(A,B) 2Fo − Fc electron density maps of (A) human BRC4 and (B) LiBRC1 at σ = 1. (C,D) Comparison of the binding modes of C-terminal LFDE motif residues in (C) HsBRC4 and (D) LiBRC1. The difference in hydrophobic pocket depth is clearly apparent. (E,F) Comparison of the residues involved in the formation of the LFDE-binding cognate hydrophobic pockets in (E) human RAD51 and (F) LiRAD51.