A histogram of the linear discriminant analysis (LDA) scores was calculated for the selected taxa which showed the significant bacterial difference between the CKD (n=44) and HCs (n=88) at the genus level. LDA score at the log10 scale is indicated at the bottom. The greater the LDA score is, the more significant the microbial biomarker is in the comparison. Based on the LDA selection, 28 genera were significantly enriched, while 7 genera were significantly reduced in CKD (n=44) compared with HCs (n=88) (all P<0.05) (Supplementary Data S9); CKD, chronic kidney disease; HC, healthy control; LDA, linear discriminant analysis.