(A) Scatter plots of serum DSG2 concentrations in healthy controls, and patients with ESCC and early-stage ESCC in the training cohort. (B) Scatter plots of serum DSG2 concentrations in healthy controls, and patients with ESCC and early-stage ESCC in the validation cohort. (C) Scatter plots of serum DSG2 concentrations from healthy controls, and patients with ESCC and early-stage ESCC in the combined cohort. (D) Scatter plots of serum DSG2 concentrations in healthy controls, and patients with EJA and early-stage EJA patients. Black horizontal lines represent mean and error bars standard error values.