The structure of PARP10 predicted by Alphafold was downloaded [66] and edited using ChimeraX [67], to annotate the predicted and known domains and modification sites. Domains were analyzed using Pfam/SMART [68]. The catalytic domain is highlighted in magenta, the ubiquitin interaction motifs (UIM) in skyblue and the RNA recognition motifs (RRM) in turquoise. Mapped automodification sites are all in the catalytic domain and are highlighted in yellow. The surface of the molecule is rendered 80% transparent to be able to appreciate the bulkiness of the molecule and at the same time visualize the domain architecture. The prediction of the flexible regions is highly uncertain. The structure was downloaded from Alphafold on 17.11.2021; the Pfam predictions on 17.11.2021.