Rescue effect of SIRT7 in oxidative stress-induced endothelial senescence in HUVECs
(A) Relative miR-335-5p level following forced SIRT7 and miR-335-5p overexpression (n=3, in all groups). (B) Western blot assay for SIRT7 in different experimental groups (n=3, in all groups). (C) Proliferation in different experimental groups (n=3, in all groups). (D) SA-β-gal staining in different experimental groups (n=3, in all groups). (E) Adhesion in different experimental groups (n=3, in all groups). (F) NO secretion in different experimental groups (n=3, in all groups). (G) Migration in different experimental groups (n=3, in all groups). *P<0.05 versus the blank or control group, **P<0.01 versus the blank or control group, ***P<0.005 versus the blank or control group, #P<0.05 versus the underlined group, ##P<0.01 versus the underlined group. Values of all groups followed a Gaussian distribution.