Multilayered organ containing stratum corneum or non-viable epidermis, the viable interfollicular epidermis consisting of keratinocytes, the vascular- and appendage-rich dermis and the subcutaneous adipose layer containing adipocytes. Biological clocks are known to regulate the behaviour of keratinocytes, fibroblasts and macrophages and may impact intercellular transfer of miRNAs via extracellular vesicles (EVs). Created in BioRender.