Figure 3
Scatter plots showing RBP interactions detected in β-catenin interactomes performed in (A) K562 cytosolic, (B) K562 nuclear, (C) HEL cytosolic and (D) HEL nuclear fractions. Vertical dashed red line indicates the threshold for 2-fold change in protein binding at log2 (= 1) relative to IgG co-IP. Horizontal red line represents threshold for significant interactions at P=0.05 on log10 scale (= 1.3). Highlighted red dots indicate statistically significant interactions and green labels indicate RBPs. Combined GO term network demonstrating biological processes of β-catenin interacting proteins found in the (E) cytoplasmic and (F) nuclear fractions of HEL, HL60 and K562 cells. Nodes (circles) in the network represent GO terms associated with the β-catenin interacting proteins. Red nodes represent GO terms with relatively high adjusted enrichment P-values (i.e., P-value is close to 0.05 which indicates term is less accurate at representing a function or process associated with the gene list). Comparatively, white nodes indicate GO terms with lower P-values close to 0. Edges (lines between nodes) representing how closely related the GO terms are to one another, with thick lines representing closely related GO terms.
β-Catenin interactions with RBPs in myeloid cells

Scatter plots showing RBP interactions detected in β-catenin interactomes performed in (A) K562 cytosolic, (B) K562 nuclear, (C) HEL cytosolic and (D) HEL nuclear fractions. Vertical dashed red line indicates the threshold for 2-fold change in protein binding at log2 (= 1) relative to IgG co-IP. Horizontal red line represents threshold for significant interactions at P=0.05 on log10 scale (= 1.3). Highlighted red dots indicate statistically significant interactions and green labels indicate RBPs. Combined GO term network demonstrating biological processes of β-catenin interacting proteins found in the (E) cytoplasmic and (F) nuclear fractions of HEL, HL60 and K562 cells. Nodes (circles) in the network represent GO terms associated with the β-catenin interacting proteins. Red nodes represent GO terms with relatively high adjusted enrichment P-values (i.e., P-value is close to 0.05 which indicates term is less accurate at representing a function or process associated with the gene list). Comparatively, white nodes indicate GO terms with lower P-values close to 0. Edges (lines between nodes) representing how closely related the GO terms are to one another, with thick lines representing closely related GO terms.

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