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Figure 7

Cumulative concentration–response curves to ACh (A) and SNP (B) (1 × 10−8 to 1 × 10−5 M) to analyse endothelium-dependent and smooth muscle-dependent vasodilation in mouse thoracic aorta, respectively (n=8) following either chronic CS or sham exposure in either IAV-infected or diluent (Dil)-treated mice subject to either ebselen (Ebs) or vehicle (Veh) treatment. Results expressed as percentage mean relaxation relative to initial preconstriction ± SEM. * indicates statistical significance P<0.05 between datasets by two-way ANOVA with Tukey’s multiple comparisons.

Ebselen treatment preserves vascular endothelial function in CS-exposed mice irrespective of IAV infection

Cumulative concentration–response curves to ACh (A) and SNP (B) (1 × 10⁻⁸ to 1 × 10⁻⁵ M) to analyse endothelium-dependent and smooth muscle-dependent vasodilation in mouse thoracic aorta, respectively (n=8) following either chronic CS or sham exposure in either IAV-infected or diluent (Dil)-treated mice subject to either ebselen (Ebs) or vehicle (Veh) treatment. Results expressed as percentage mean relaxation relative to initial preconstriction ± SEM. * indicates statistical significance P<0.05 between datasets by two-way ANOVA with Tukey’s multiple comparisons.

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