Functional ‘modes’ of xenobiotic interactions with mitochondrial metabolism and accompanying changes in empirical measurements
Diagram relating specific modes of xenobiotic interactions with effects on the mitochondrial energy transduction system. Empirical measurements in isolated mitochondria and/or subcultured cells are emphasized. JO2 is mitochondrial respiration. ΔΨm is the mitochondrial inner membrane potential. QEff is the apparent coupling efficiency of OxPhos, typically determined from titration of an ATP synthase inhibitor. ROS is reactive oxygen species (e.g. rate of H2O2 production). Arrows indicate anticipated direction of change upon interaction. Up/down arrows indicate increase or decrease, respectively. Horizontal double arrows indicate variable change. Circles indicate no change. Abbreviation: Rxns, Reactions.