The naive and activated T cells are labeled. The resting naive T cells metabolize glucose primarily via the high energy-yielding mitochondrial oxidative phosphorylation pathway. On activation, the glucose uptake is enhanced due to up-regulation of GLUT1 expression. The cells switch to aerobic glycolysis and lipid oxidation to produce biosynthetic precursors, this enhancing cell growth and proliferation. The TCR signaling modules cross-talk with the glucose metabolism are shown.