Vehicle-treated retinas (A,C,E) showed extensively disorganized and disrupted vasculature. Vehicle-treated mice showed the presence of continuous and twisted capillaries that were folded on themselves and resembled large microaneurysms, vascular tufts and IRMAs (white boxes; A,C), tortuous vessels (white arrows; A,C) and capillary non-profusion (green asterisk; A,C,E). In addition, diffused staining indicative of loss of vessel integrity and leakage (yellow arrow; C) and wide distribution of monocytes/macrophages (blue arrow heads; A,C,E) were observed. EMPA-treated retinas (B,D,F) showed a better overall retinal vascular integrity and organization. The presence of smaller microaneurysms, vascular tufts and IRMAs (white boxes; B,D), less tortuous vessels (white arrows; B,D), minimal capillary non-profusion (green asterisk; B,F) and a lower distribution frequency of monocytes/macrophages (blue arrow heads; F) were observed. Scale bars = 100 μm.