(A) Schematic representation of nucleosome uncoiling in front of the replication fork and parental histone redeposition onto duplicated DNA. (B) Modelled interactions between Dpb3–Dpb4 and histones H3–H4 based on the homology with histones H2A–H2B. (C) The structure of full-length Pol epsilon. (D) The rigid structure of full-length Pol epsilon would be able to accommodate an H3–H4 interaction with unstructured Dpb3–Dpb4 tails but not a histone-core-like engagement.