(A) VEGFR and KIT inhibitors. (B) BRAF inhibitors. (C) MEK inhibitors. In 3D images, structures of the superimposed kinases are shown with their bound inhibitors. Full kinase inhibitor structures are represented with transparent white surface and stick models. RS3 Leu is shown with transparent yellow surface and sticks. The RS3 interacting atoms of the inhibitors are highlighted in 2D-structures of the structural moieties that are located near the RS3 residue. Hydrophobic interaction was defined based on a 3.6 Å (or shorter) distance between two hydrophobic atoms.