Implementing YAP levels as prognostic indicator of YAP activity
Scatter-plot showing correlation between total YAP levels and levels of pYAP (S127) in patients across a range of cancer types. A strong and significant positive correlation exists between the levels of the two proteins, indicating that in patients with high levels of pYAP (S127), a concurrent increase in total YAP levels is observed. Points shown comprise RPPA data across the pan-cancer dataset (obtained from the Genomic Data Comms portal; https://gdc.cancer.gov/), normalised across cancer subtypes (level 4). Correlation coefficients and P-values were determined via Spearman method.