Protein schematics showing the structures and domains of YAP/TAZ proteins (left) and common fusion partners in specific cancers (right). The location of frequent fusion breaks are denoted (red dashed lines), with common fusions and associated cancer types highlighted in red resulting in chimeric transcription factors. TAZ is encoded by WWTR1. Abbreviations: AD, acidic domain; ANK, ankyrin repeat region; bHLH, basic helix–loop–helix; CC, coiled-coil domain; CG-1, CG-1 DNA-binding domain; Glut, glutamine-rich region; IQ, IQ calmodulin-binding motif; LZ, leucine zipper; MAML, mastermind-like domain; PDZ, PDZ-binding domain; Prol, proline-rich region; ser, serine-rich region; TIG, transcription factor immunoglobulin domain.