Figure 2.
![Thorel et al. [57] found similar α to β cell trans-differentiation de novo after an extreme loss of β cells. However, the conversion and the rescue process took very long time compared with the viral-mediated α to β cell trans-differentiation.](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/6/10.1042_bst20210244/1/bst-2021-0244c.02.png?Expires=1717035445&Signature=D03V4tEl6p7gj8O9E~M1FuoxZJSIdW~Z4dABpZ5I7P8-D11R4-clTxt~aKne2HvlqR-MephUXci2ksF1DE-GpwfrhkW74WUZCeJLzhdxmXKduDRIwaDYhOGZXX2gkGa3CfBDlgkJQ~3xkWMLsY7mjgNFXvi8~Bkj0ZcgoJMPgDQ7NjCwT1ElE3TEC1FNmFY2VFDhM581k3EqCNXmA4DHKaT748t8NQB7NBQY~4yTJgJTfoZdM54FJToWS2PgmtZLaEx0Crt0fKQ9RVNXk6Sgc1arURMq369hk6c3UmsTVn2tfffPVylOC7CR0kNgfX9Lm1hM8BrBf-bd4O~w6y7vdw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
In NOD mice with hyperglycemia, pancreatic intraductal infusion of adeno-associated virus-containing pdx1 and MafA converted α cells into β cells and restored normoglycemia.
Thorel et al. [57] found similar α to β cell trans-differentiation de novo after an extreme loss of β cells. However, the conversion and the rescue process took very long time compared with the viral-mediated α to β cell trans-differentiation.