Figure 2.
![Highlighted factors (blue) are more abundant in the aged cells and exert specific activation of transcript translation (red arrow) and global reduction in protein synthesis (blue block) [48,67,71,72].](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/6/10.1042_bst20210844/1/bst-2021-0844c.02.png?Expires=1717058690&Signature=HKS3E5xsBY3U~M6Ia3C8URSuAlDsN25byLAIwLjaNH1gAh5YIQuXVfTVF9fER8X5GNHvPzwSAX0sEKbpTrBpjQVAGEDdzweYwfecaGi6BEJkJgVm83mKg6JEIlFsvmXXWwbpcZxcDt9mFNuTeUG~EvhGtGz8sem8eRpPr-L-ilMe563EDDiJjAg2wx5xoSiZduSI8xDWl3KQHeNI6jsEe~pmmom4MAnWbx6KA-XKf8JabDs5CHfagJOM9hAOibsXNJcdEbfPc-MjZgXT0bFI3xA2ujdrBQqUEvQF6Eqqkz472M1DbGc03vIPzLEouUXcJqHRftFml6FcPULSsd6Bcg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Integrated Stress Response (ISR) pathways are implicated in the aged cell phenotype.
Highlighted factors (blue) are more abundant in the aged cells and exert specific activation of transcript translation (red arrow) and global reduction in protein synthesis (blue block) [48,67,71,72].