Figure 2.
![(A) Amino acid substitutions in variants of concern (VOCs) mapped on spike protein [71]. (B) Cryo-EM structures of the spike protein (Protein Data Bank: 7DDN). Two orthogonal views, from the side and top, of the atomic model of the partially open spike trimer [93]. Blue and purple domains indicate the NTD and RBD (open), respectively. (C) Efficacy of neutralizing antibodies in clinical use against VOCs. This table summarizes the sensitivity of each monoclonal antibody to VOCs, but in practice, neutralizing antibodies are used in combination as a cocktail.](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/6/10.1042_bst20210859/1/bst-2021-0859c.02.png?Expires=1716641217&Signature=em4F94KJ0h34UgPAGOFS66hr5SgKwMCam8KnErnL1RTxJszSR16iXIl0xqjAotC0K~8PM~CQRURVhwhkZk7o13n8JK3rvJyoExzno3NkRUjl7n6tdY7l8Yz5LOWjr4zc-6xSNcl6h3ONbH9mHQXyscAM1IDMUlvKglgtmIyp-REgacPLOQvg6wEtwmyr7512fHWpd9RD5xgxQrlp9ZxLfBz1ixNl~Y72P2T6AXZ7ign1~ykDzRkpqxlclc~kQCm4NXJoc4mOyj4VS7GOv89akUS3B9DiLVGZsNDaEOg9MuG5d0w6pBXhQEki9orh-V6LPfE1aSbFdfOU43cPC~iiUw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Variants of concern escape from antibodies in clinical use.
(A) Amino acid substitutions in variants of concern (VOCs) mapped on spike protein [71]. (B) Cryo-EM structures of the spike protein (Protein Data Bank: 7DDN). Two orthogonal views, from the side and top, of the atomic model of the partially open spike trimer [93]. Blue and purple domains indicate the NTD and RBD (open), respectively. (C) Efficacy of neutralizing antibodies in clinical use against VOCs. This table summarizes the sensitivity of each monoclonal antibody to VOCs, but in practice, neutralizing antibodies are used in combination as a cocktail.