Figure 1.
![(a) Folds of tau protein in the cores of filaments from various diseases: Alzheimer's disease, chronic traumatic encephalopathy, Pick's disease and corticobasal degeneration. A side view of the Alzheimer PHF is also shown. (b) Folds observed in heparin assembled filaments do not match any of the disease folds. (c) Sequence of the repeat region of tau, showing the part of the sequence in each core filament and the segments corresponding to the β-strands. Reproduced with permission from Scheres et al. [36].](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/6/10.1042_bst20210719/1/bst-2021-0719.01.png?Expires=1716549304&Signature=fElekN~kTywC2FSUL1LX7K~DiK9xbzYrMcxyoJJrnAK2vcNM6x5wA9OsitsmMTBpRt7NgRWVvtX7qSkx8JHBrinKF-rrKxuz0dafLq-EoylMqd690YKhPKVpqnyAWYK3YvEMYNgtYHocn0sS6rmev1WHPgBnzE68lOwc23aH4v4GbNl8OgPtvenRZObA78i5587-Bd8yn4bQZMirTFVMU1wY0x40Rx~eeN0ju4Oa~MrKzo8fctq8z04PWrg1yzyeSJXuacb3SBAqVBBbLzII1f6Cp4erWkI8yhvcF2jNYMzCC5Ytj~BFvN~OAvTKsrfTItaLhSpVkUrso01LdhOQtQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Structures of tau filaments.
(a) Folds of tau protein in the cores of filaments from various diseases: Alzheimer's disease, chronic traumatic encephalopathy, Pick's disease and corticobasal degeneration. A side view of the Alzheimer PHF is also shown. (b) Folds observed in heparin assembled filaments do not match any of the disease folds. (c) Sequence of the repeat region of tau, showing the part of the sequence in each core filament and the segments corresponding to the β-strands. Reproduced with permission from Scheres et al. [36].