Expression of SARS-CoV-2 receptors in human cardiac PCs in situ
Immunofluorescence stainings showing PCs in the human heart. (A,B) Identification of CD31−CD34+PDGFRβ+ PCs around microvessels. CD31 recognises the vessel lumen, the CD34 labels both the luminal ECs and perivascular PCs, while PDGFRβ labels both PCs and vascular smooth muscle cells (VSMCs) in the arteriole’s tunica media. (C–F) A subset of PDGFRβ+ cardiac PCs express ACE2 (C,D) and CD147 (E,F). α-SMA labels some PCs and arterioles’ VSMCs (C,D), while vWF recognises ECs (E,F). CD147 is also expressed by ECs (E,F). Arrowheads point to PCs.