(A) Heatmap exhibiting the correlation between THUMPD1 and 47 ICP genes expression in 33 cancer types from TCGA database. The left bottom triangle in each unit represents coefficient of association, computed by Pearson’s correlation test; the triangle in the upper right represents the P-value in log10 format. *P<0.05, **P<0.01, ***P<0.001. (B) Survival analysis for low (n=127) and high (n=221) THUMPD1 expression groups from clinical cohorts receiving anti-PD-L1 immunotherapy. (C) Proportion of patients with therapeutic response to PD-L1 blockade immunotherapy in low and high THUMPD1 expression cohorts. Cut-off point was determined at the maximal statistic rank. Abbreviations: CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease. Response/non-response = 15/85% in low THUMPD1 expression group and 27/73% in high THUMPD1 expression group. Abbreviation: PD-L1, programmed cell death protein 1 ligand.