(A) DISC1 serves as a tether for mitochondria, RNA (brown strands), RNA particles (yellow) and SVs filled with transmitter (pale blue). DISC1 binds to a kinesin motor complex to regulate transport of various cargo into dendrites (blue arrows) and/or nerve terminals (purple arrow). (B) DISC1 binding to IP₃Rs within MAMs lowers the amount of Ca²⁺ transferred via VDAC channels into mitochondria, protecting them from excitotoxicity. DISC1 does not appear to regulate ER Ca²⁺ release by the ryanodine receptor 2 (RYR2).