Schematics of DISC1 organization and key interaction sites
(A) DISC1 mRNA is composed of 13 exons. Red arrows denote the translocation break site in the Scottish family and the 4-nucleotide deletion from the American family. Blue arrows show RNA locations that give rise to amino acid substitutions, which result in altered nerve cell function and/or behavior. Gray bars identify RNA sequences that give rise to DISC1 self-association and oligomerization. (B) Schematic of full length 854 amino acid DISC1 protein showing its putative globular or disordered head region and a long coiled-coil region. The relative bindings sites are shown for key proteins (blue bars) and mRNA (red bar).