Figure 8.
![(A) Loose-patch membrane current recordings in (a) WT, (b) Scn5a+/− and (c) RyR2-P2328S/P2328S atria. (B)(a) The resulting maximum peak inward currents (# P < 0.005). (b) Maximum upstroke rates ((dV/dt)max) and (c) waveforms showing conduction delays in left atrial intracellular action potentials. (Adapted from Figure 5 by permission (King et al. [50]).](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/5/10.1042_bst20200604/1/bst-2020-0604c.08.png?Expires=1716508880&Signature=ZnW3va5nqv1HmIbmr1D13XUaKYvB5FybuS8Ahr8XZt2nULbilJ9J5UOMi~rc1Ik4geXpoHitIDmF4O2bBTkf3lGuR~xjq4fOZM2G~MMbTlzLMna43zs5VQZc5h6tdHrFv2k9pC2bwC3GaX9MVUBIGTdlW9HQen3fFIrmJwiBnqQdci8uY~PkgF-NEZKZKFWH-1JeIT~9GTMjdzqquiZDMSxhJflAc~sMajxhehvGFpjFOK78S6YlTDO8XBZrQgAoFfHhPdD4MYYPtIRxa8JDpLpJlRik3np9ji7bjHvmqMZ7FhIETzjLXgUWGN85iFVy6h37fBTZm9qV6a9939nr5w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Altered Na+ current function paralleling Na+ channelopathy occurs in a murine pro-arrhythmic catecholaminergic polymorphic ventricular tachycardia model.
(A) Loose-patch membrane current recordings in (a) WT, (b) Scn5a+/− and (c) RyR2-P2328S/P2328S atria. (B)(a) The resulting maximum peak inward currents (# P < 0.005). (b) Maximum upstroke rates ((dV/dt)max) and (c) waveforms showing conduction delays in left atrial intracellular action potentials. (Adapted from Figure 5 by permission (King et al. [50]).