(A) The levels of Scr in different groups. Compared with the control group, Scr level was markedly elevated in CKD rats and declined after PE or JPYSF treatment, especially in the combined treatment group. (B) The levels of BUN in different groups. PE, JPYSF and combined treatment reduced the BUN levels of CKD rats. Data are presented as the means ± SEM, n=4–6 rats per group (***P<0.001 compared with the control group; ^##P<0.01, ^###P<0.001 compared with the CKD group; ^†P<0.05, compared with the CKD+PE+JPYSF group; ns, no significance).