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Figure 6

$(A) A waterfall plot of the top 50 mutated genes in CRC patients. (B) Different immunocyte fractions in high and low TMB groups. CD8+ T cells, memory activated CD4+ T cells, follicular helper T cells, regulatory T cells, activated NK cells, M0 macrophages, and M1 macrophages had a P-value <0.05. (C) A difference in the immunoscore between high and low TMB groups (P=0.0113). (D) Kaplan–Meier curves for overall survival based on the TMB group (P>0.05). (E) The ability of the immunoscore to identify poor prognostic patients in the high TMB group is shown in (E).$

Mutations in CRC patients, and the distribution of immunocytes based on different TMB scores

(A) A waterfall plot of the top 50 mutated genes in CRC patients. (B) Different immunocyte fractions in high and low TMB groups. CD8⁺ T cells, memory activated CD4⁺ T cells, follicular helper T cells, regulatory T cells, activated NK cells, M0 macrophages, and M1 macrophages had a P-value <0.05. (C) A difference in the immunoscore between high and low TMB groups (P=0.0113). (D) Kaplan–Meier curves for overall survival based on the TMB group (P>0.05). (E) The ability of the immunoscore to identify poor prognostic patients in the high TMB group is shown in (E).

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